ANTIBIOTICS (cephalosporins )
CEFUROXIME :
IT IS RESISTANT TO MOST BETA - LACTAMASES AND IS ACTIVE AGAINSTA WIDE RANGE OF GRAM - POSITIVE AND GRAMNAGATIVE ORGANISMS. THE MOST IMPORTANT USE OF CEFUROXIME IS IN MENINGITIS CAUSED BY H. INFLUENZAE, MENINGOCOCCI AND PNEUMOCOCCI, BECAUSE IT ATTAINS HIGH CONCENTRATIONS IN C.S.F.
INDICATIONS :
RESPIRATORY TRACT, GENITO - URINARY TRACT, SKIN AND SOFT TISSUE INFECTIONS, GONORRHOEA, ACUTE GONOCOCCAL URETHRITIS AND CERVICITIS MENINGITIS, PROPHYLAXIS AGAINST INFECTIONS IN SURGICAL PROCEDURES
DOSAGE :
ADULTS :
750 MG THRICE DAILY I.M OF I.V. SEVERE INFECTIONS :
1.5 G, THRICE DAILY I.V. TOTAL DOSE 3 - 6 GM DAILY.
INFANTS AND CHILDREN :
30 - 100 MG/ KG BODY WIGHT
DAILY IN 3 - 4 DIVIDED DOSES.
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