ANTIBIOTICS (cephalosporins )

CEFUROXIME : 

IT IS RESISTANT TO MOST BETA - LACTAMASES AND IS ACTIVE AGAINSTA WIDE RANGE OF GRAM - POSITIVE AND GRAMNAGATIVE ORGANISMS. THE MOST IMPORTANT USE OF CEFUROXIME IS IN MENINGITIS CAUSED BY H. INFLUENZAE, MENINGOCOCCI AND PNEUMOCOCCI, BECAUSE IT ATTAINS HIGH CONCENTRATIONS IN C.S.F.


INDICATIONS :

RESPIRATORY TRACT, GENITO - URINARY TRACT, SKIN AND SOFT TISSUE INFECTIONS, GONORRHOEA, ACUTE GONOCOCCAL URETHRITIS AND CERVICITIS MENINGITIS, PROPHYLAXIS AGAINST INFECTIONS IN SURGICAL PROCEDURES


DOSAGE :

ADULTS : 

750 MG THRICE DAILY I.M OF I.V. SEVERE INFECTIONS : 

1.5 G, THRICE DAILY I.V. TOTAL DOSE 3 - 6 GM DAILY.

 

INFANTS AND CHILDREN :

30 - 100 MG/ KG BODY WIGHT  
DAILY IN 3 - 4 DIVIDED DOSES.

NEONATES :

100 MG / KG BODY WIGHT IN 2 -3 DIVIDED DOSES


CONTRA - INDICATIONS :

PATIENTS WITH KNOWN HYPERSENSITIVITY 

TO CEPHALOSPORIN ANTIBIOTICS.


SPECIAL PRECAUTIONS :

ANAPHYLACTIC REACTION TO PENICILLINS.  

PSEUDOMEMBRANOUS COLITIS. OVERGROWTH OF 

NON - SUSCEPTIBLE ORGANISMS.


PAEDIATRICS :

NOT SAFE IN CHILDREN BELOW 3 MONTHS


PREGNANCY :

USE WITH CAUTION.


LACTATION :

USE WITH CAUTION 


SIDE - EFFECTS :

SKIN RASHES, EOSINOPHILIA AND 

TRANSIENT INCREASE OF HEPATIC ENZYMES.


DRUG INTERACTIONS :

SYNERGY WITH AMINOGLYCOSIDES.


Comments

Popular posts from this blog

T - Minic oral drops ( FOR CHILDREN )

vasograin tablet

styptovit - E tablets